血浆炎性趋化因子CXCL9/Mig水平与急性移植物抗宿主病关系的研究

           作者：冀林华　任汉云　石永进　岑溪南　邱志祥　欧晋平　许蔚林

【摘要】  　　研究血浆炎性趋化因子CXCL9/Mig在异基因造血干细胞移植（allo-HSCT）前后的水平变化，以探讨该因子在急性移植物抗宿主病（aGVHD）发病中的作用。以35例异基因造血干细胞移植患者为研究对象，其中包括发生0-Ⅰ度aGVHD者13例，Ⅱ度aGVHD者12例，Ⅲ-Ⅳ度aGVHD者10例。采用固相双抗体夹心ELISA 方法分别测定造血干细胞移植前、临床aGVHD发生前1周、aGVHD高峰时、aGVHD完全控制后血浆CXCL9/Mig水平。结果表明：中、重度aGVHD（Ⅱ-Ⅳ度）发生时血浆CXCL9/Mig水平明显升高( P<0.001)，且随aGVHD严重程度加重而增加；临床aGVHD表现出现前1周，血浆CXCL9/Mig水平已明显升高( P<0.001)。血浆CXCL9/Mig水平与巨细胞病毒（CMV）感染等感染并发症无明显相关性（P＞0.05）。结论： CXCL9/Mig血浆水平与aGVHD的发生明显相关，表明该因子在aGVHD发生中发挥重要作用。异基因造血干细胞移植后动态观察血浆CXCL9/Mig水平变化可作为aGVHD早期诊断的有价值的指标，进而达到早期干预aGVHD提高异基因造血干细胞移植效果的目的。

【关键词】  急性移植物抗宿主病;炎性趋化因子；CXCL9/Mig；异基因造血干细胞移植

　　Increment  of Chemokine CXCL9/Mig in Plasma Correlated with Acute Graft-versus-Host Disease after Allogeneic Hematopoietic Stem Cell Transplantation

　　　AbstractTo investigate the relationship between the plasma levels of chemokine CXCL9/Mig and acute graft-versus-host disease (aGVHD) after allogeneic hematopoietic stem cell transplantation（allo-HSCT）.The plasma levels of CXCL9/Mig of 35 patients who received all-HSCT were detected by using ELISA assay，these patients included 13  patients with grade 0-Ⅰ，12 patients with grade Ⅱ and 10 patients with grade Ⅲ-Ⅳ aGVHD，respectively. The four different  time points including prior to allo-HSCT, one week before aGVHD onset, the plateau of aGVHD and  time after completely controlled, were studied. The results showed th

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