宫颈癌同步放化疗前后HPV DNA及TNF

【关键词】  中晚期宫颈癌；同步放化疗；HPV；TNF

　　Changes of  HPV DNA and TNFα levels in patients with advanced cervical cancer before and after concurrent chemoradiotherapy

　　【Abstract】 AIM: To analyze the changing of HPV DNA in cervical secretions and serum TNFα level in patients with advanced cervical cancer before and after concurrent chemoradiotherapy. METHODS: The level of HPV DNA was tested by HC2 and TNFα by ABCELISA in 30  patients with advanced cervical cancer(reseach group) before and after chemoradiotherapy and 20  healthy women as the controls. RESULTS: The HPV infection rate before treatment(96.7%) was higher than that after treatment (20%) and  in normal controls(10%). The negative conversion rate at the end of treatment  was 79.3%(23/29). The levels of serum TNFα before and after chemoradiotherapy ［(134.15±77.99) and (113.14±79.99) pg/mL respectively］were both higher than that in normal controls［(54.91±13.19) pg/mL, P<0.01］. Serum TNFα levels had no significant difference between pretreatment and posttreatment (P>0.05), but a tendency of decreasing existed. CONCLUSION: The detection of HPV DNA in cervical secreations and serum TNFα might be useful reference indexes for diagnosis and judging prognosis or curative effect.

　　【Keywords】 advanced cervical cancer; chemoradiotherapy; human papilloma virus; tumor necrosis factor α

　　【摘要】  目的： 观察中晚期宫颈癌患者同步放化疗治疗前、后宫颈分泌物HPV DNA及血清TNFα含量的变化趋势. 方法： 采用第二代杂交捕获技术(HC2)和双抗体夹心ABCELISA法检测30例中晚期宫颈癌患者（实验组）同步放化疗治疗前、后宫颈分泌物HPV DNA及血清TNFα的含量，并与

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