内皮细胞损伤、血小板活化及功能状态与2型糖尿病的相关性

【关键词】  内皮损伤

　　Correlation between vascular endothelial cell injury, platelet activation and functional status in type 2 diabetes

　　【Abstract】 AIM: To investigate the vascular endothelial cell injury and the platelet activation and functional status change  in type 2 diabetes patients. METHODS: The plasma levels of von willebrand factor∶antigen (vWF∶Ag) and granule membrane protein140（GMP140）were measured by double sandwich ELISA. The adhesiveness of platelet was determined by Salzmans method. RESULTS: The plasma levels of vWF∶Ag（145.6±25.6）％，GMP140（16.8±3.5）μg/L and PAdT （80.3±5.3）％ of type 2 diabetes were significantly higher than those of normal controls（P<0.05）; The plasma levels of these markers in the group of type 2 diabetes with vascular complication were higher than those in the one without vascular complication（P<0.05）; plasma levels of GMP140 and PAdT were positively correlated with those of vWF∶Ag［（160.8±35.6）％，（18.9±5.5）μg/L，（89.5±7.8）％, r=0.446, 0.413, P<0.05］. CONCLUSION: Type 2 diabetes can cause vascular endothelial cell injury, platelet activation and functional status change. The plasma levels of vWF∶Ag, GMP140 and PAdT may reflect vascular pathological changes in type 2 diabetes patients to a certain extent.

　　【Keywords】 diabetes； endothelial cell injury；platelet activation；angiopathies

　　【摘要】 目的： 观察2型糖尿病患者内皮细胞损伤、血小板活化及功能状态的变化及临床意义. 方法： 利用双抗体夹心 ELISA法测定血浆血管性血友病因子抗原vWF∶Ag，血小板膜表面α颗粒膜蛋白GMP140水平；采用玻珠柱法测定血小板黏附率PAdT. 结果： 糖尿病组血浆vWF∶Ag（145.6±25.6）％，GMP140（16.8±3.5）μg/L，PAdT（8

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