【关键词】 青蒿素；癌,Lewis肺；淋巴管生成；血管内皮生长因子
Effect of artemisinin on metastatic tumor growth and lymphangiogenesis in mice bearing Lewis lung carcinoma
【Abstract】 AIM： To explore the effect of antimalarial artemisinin on Lewis lung carcimoma (LLC) growth and tumor lymphangiogenesis. METHODS： The models of LLC in C57BL/6 mice were established via subcutaneous injection of mouse LLC cells. After mice were orally administered with artemisinin at 50 mg/kg body weight, once 2 d for 2 weeks, tumors were measured with calipers twice weekly. Mice were sacrificed 30 d following tumor cell injection, and Lewis tumors and lungs were harvested and weighted. Lewis tumors and lungs were processed for immunohistochemical analysis for lymphangiogenesis using VEGFR3 and LYVE1 staining or for micrometastasis using HE staining. Lymphatic microvessel density (LMVD) was evaluated by LYVE1 positive lymphatic vessel count. Furthermore, mice were monitored for survival studies. RESULTS： LMVD, wet weight of lungs and number of lung metastasis in artemisinintreated group were significantly lower as compared with control group (P<0.05). However there was not statistically significant difference in tumor growth between artemisinintreated mice and control mice (P>0.05). In add
| 相关热词搜索 |
关于青蒿,蒿素,素对,对小,小鼠,鼠L,Le,ew,wi,is,s肺,肺癌,癌移,移植,植瘤,瘤生,生长,长和,和淋,淋巴,巴管,管生,生成,成的,的影相关信息> 更多 博士论文【点击次数排列】更多>>
