无损光学法测量胃壁组织对KTP/Nd:YAG激光的光学特性的差异

【摘要】  目的  研究人正常胃黏膜及黏膜下层组织对532nm和1064nm波长的KTP/Nd:YAG激光的光学特性及其对不同波长的激光的光学特性差异。方法  实验采用激光斜入射式空间分辨反射光和CCD探测器以及非线性拟合确定组织光学特性。结果  正常人胃黏膜/黏膜下层组织对1064nm的激光的吸收系数(0.145±0.004)mm-1明显地较其对532nm的激光的吸收系数(0.314±0.008) mm-1要小(P＜0.05)，组织样品对1064nm的激光的约化散射系数(0.713±0.019)mm-1明显地较其对532nm的激光的约化散射系数(1.49±0.04)mm-1要小(P＜0.05)，组织样品对1064 nm的激光的光学穿透深度(1.73±0.05)mm明显地较其对532 nm的激光的光学穿透深度(0.814±0.021)mm要大(P＜0.05)，组织样品对1064nm的激光的漫射系数(0.436±0.011)mm明显地较其对532 nm的激光的漫射系数(0.208±0.006)mm要大(P＜0.05)。结论  正常人胃黏膜/黏膜下层组织对1064 nm的激光的吸收系数与其对532 nm的激光的吸收系数的差异为53.8%，其对1064 nm的激光的约化散射系数与其对532 nm的激光的约化散射系数的差异为52.2%，其对1064 nm的激光的光学穿透深度与其对532 nm的激光的光学穿透深度的差异为113%，其对1064 nm的激光的漫射系数与其对532 nm的激光的漫射系数的差异为110%。
   
　　【关键词】  人胃黏膜/黏膜下层组织；光学特性差异；激光；CCD探测器；空间分辨漫反射光
 
　　Noninvasive measurements for differences in optical properties of stomach tissues at KTP/Nd:YAG laser using optical methods

　　　　【Abstract】  Objective  The study is to determine the optical properties and their differences for normal human stomach mucosa/submucosa tissues in vitro at 532 and 1064nm KTP/Nd:YAG laser.Methods  The measurements were performed using a CCD detector，and the optical properties were assessed from the measurements using an obliquely incident laser beam，and spatially resolved reflectance，and nonlinear fitting of diffusion equation.Results  The absorption coefficient，(0.145±0.004)mm-1 of normal human stomach mucosa/submucosa tissues at 1064 nm is obviously smaller than that (0.314±0.008) mm-1 of the tissue samples at 532 nm (P＜0.05)，and the re

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