盐酸洛拉曲克对小鼠移植肿瘤抑制作用的实验研究

         作者：吕慧敏，杜维霞，付颍华，周湘艳，董金婵

【摘要】  目的  观察盐酸洛拉曲克（THY-110）对小鼠移植肝癌(H-22)、艾氏腹水癌(EAC)和肉瘤(S-180)的抑制作用。方法  实验采用昆明小鼠，体重18～22g，雌雄各半。设80、120和180mg/kg体重3个给药剂量组，一个阳性对照组和一个溶剂对照组。小鼠经左前肢腋下接种0.2ml（1×107/ml）肿瘤细胞悬液，接种后连续腹腔注射给药10天。停药后剥离出肿瘤并称瘤重，计算肿瘤抑制率，试验重复3次。结果  盐酸洛拉曲克对肝癌、艾氏腹水癌及肉瘤的抑瘤率高、中和低剂量组分别为：(70.23±3.1)%，(66.3±6.2)%，(46.8±3.7)%；(69.1±1.4)%，(59.7±6.6)%，(43.8±5.9)%；(73.8±1.7)%，(64.1±4.2)%，(42.2±4.7)%。结论  盐酸洛拉曲克具有显著的抑制肿瘤作用。
   
    【关键词】  盐酸洛拉曲克（THY-110）；移植；肿瘤抑制率
   
    Study on effect of tumor control by abdominal cavity injection of THY-110 for mice
   
    LU Hui-min， DU Wei-xia，FU Ying-hua，et al. Institute of Radiological Protection and Nuclear Safety， China CDC， Beijing 100088， China
   
    【Abstract】  Objective  To investigate the treatment effect of liver cancer H-22， EAC cancer and S-180 by abdominal injection of THY-110 in mice.Methods  Mice were divided to five groups including THY-110 doses groups of 80， 120 and 180mg/kg body weight；solvent group and positive control group. 0.2ml（1×107/ml） tumor cell solution were inoculated to mice at fore limb subaxilla. After inoculation， mice were continuously injected of THY-110 for 10 days， tumor tissues were peeled off and weighted， the lessening rate

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